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Structural mechanism governing the directionality of bridge recombination

Nature · first seen 12.08.2026

Cryo-electron microscopy structures revealed how IS621 bridge recombinase mediates DNA excision, informing the design of programmable bridge-editing tools.

  • Cryo-EM structures show how IS621 bridge recombinase mediates DNA excision.
  • Explains natural preference for insertion.
  • Informs design of programmable bridge-editing technologies.

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